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MDMB-4en-PINACA (also incorrectly known as 5-CL-ADB-A) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. 

MDMB-4en-PINACA differs from 5F-MDMB-PINACA due to replacement of 5-fluoropentyl with a pent-4-ene moiety (4-en).

It acts as a potent agonist of the CB1 receptor with an EC50 value of 2.47 nM 

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MDMB-4en-PINACA is a new synthetic indazole cannabinoid. MDMB-4en-PINACA is analogous to 5F-MDMB-PINACA and has a similar molecular structure. 

MDMB-4en-PINACA might display high affinity for peripheral CB1 and CB2 cannabinoid receptors. MDMB-4en-PINACA is marketed online as the designer drug cannabinoid

The side-effects of MDMB-4en-PINACA are unknown.

Storage conditions of this chemical: in a cool and dry place.

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MDMB-4en-PINACA is a synthetic cannabinoid receptor agonist (SCRA) that has recently emerged. Data regarding clinical presentations in the event of intoxication is scarce. 

This study presents MDMB-4en-PINACA identification in cannabis consumers with clinical and analytical descriptions.

A new class of synthetic cannabinoids has emerged as new psychoactive substances (NPS). Similar in structure to JWH-022, these substances contain alkene modifications to the tail region of the synthetic cannabinoid core structure, and nomenclature denotes these new analogues as pent-4en or but-3en species. Internationally, two analogues from this new series recently emerged: 

MDMB-4en-PINACA and MMB-4en-PICA. Previously, data regarding activity and potential toxicity were not available. 

In vitro assessment of cannabinoid receptor 1 (CB1) activation via the β-arrestin 2 recruitment was studied for three pent-4en analogues, one but-3en analogue, and one principal metabolite. MDMB-4en-PINACA (2.47 nM, 239%), MDMB-4en-PICA (11.5 nM, 302%), and MDMB-3en-BINACA (14.3 nM, 286%) were highly potent and efficacious (comparison: JWH-018, 25.3 nM, 100%), while the potencies of MMB-4en-PICA and MDMB-4en-PINACA 3,3-dimethylbutanoic acid were markedly lower. 

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HU-210 is a synthetic agonist analog of Δ9-THC, which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1) 

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